
比爾·蓋茨建議,為美國60歲以上人群的常規體檢增加一項新內容:通過血液檢測篩查阿爾茨海默癥風險,并據此提供早期預防性用藥。
這位微軟(Microsoft)創始人長期積極參與全球疾病預防項目。未來幾年,他或將進一步加大在該領域的行動力度。蓋茨已向其慈善基金會下達新任務:他將把自己絕大部分財富(約1,000億美元)捐贈給該基金會,條件是須在未來20年內將這筆資金全部投入使用。
連同現有資產與預期增長在內,其基金會未來可支配的資金總額預計將達到約2,000億美元,重點用于攻克可預防疾病,其中包括蓋茨尤為關注的阿爾茨海默癥。這位科技巨頭的父親老比爾·蓋茨曾罹患阿爾茨海默癥,于2020年去世,享年94歲。
蓋茨對阿爾茨海默癥等疾病的治愈前景有著獨特見解,這不僅源于他的家庭親歷——其家人曾受到這種導致記憶與認知能力退化的腦部疾病影響,也因為他作為全球公共人物,能直接影響各國政策制定者與決策層。
蓋茨指出,從美國的經濟與社會層面來看,治愈阿爾茨海默癥等疾病不僅能減輕家庭負擔,也能緩解社會福利制度的壓力。
蓋茨在接受CBS《周日早晨》節目采訪時表示:“當一個國家進入老齡化社會時,就會出現大量慢性疾病,這些疾病會消耗大量資源。”未來,富裕且老齡化程度較高的國家將從應對急性病轉向應對慢性病?!耙虼耍辛α抗タ藥追N主要疾病是非常明確的當務之急,其中阿爾茨海默癥首當其沖。”
蓋茨目前正資助多家機構研發基于血液的診斷測試,用以檢測一種名為“淀粉樣蛋白”的特定物質——它被視為阿爾茨海默癥早期發展的關鍵標志物。
蓋茨補充說,理想狀態下,患者應在出現任何癥狀之前就能得到治療。當被問及是否應將阿爾茨海默癥檢測納入常規體檢時,他回答道:“對普通人群而言,大概從60歲起,這應該成為常規血液檢測的一部分。這種檢測成本相對較低,如果這些方法被證明有效,且副作用降低,就應該被納入常規體檢。如果血液檢測顯示淀粉樣蛋白水平偏高,患者就能獲得相應的清除藥物保障?!?/p>
蓋茨表示,這類藥物未來可能以自我注射或靜脈輸液的方式使用,以預防阿爾茨海默癥的發生。但他也指出,要實現這一目標,“仍需完成若干關鍵步驟”。
一直工作到九十歲
人類健康壽命延長帶來的另一個好處是,勞動力規模隨之擴大。當前,各國的決策者既要面對老齡化人口帶來的護理與財政壓力,又要解決因出生率下降而導致的勞動力不足問題。
但蓋茨認為,得益于疾病預防的進步,只要人們愿意,完全可以延長工作年限,在高齡階段繼續從事有意義的工作。這有助于緩解因醫療成本增加而加重的勞動力壓力,從而重新平衡經濟運行所需的人力資源。
他補充說,有些人可能會對這些想法持懷疑態度,“很多人看到一些社會趨勢時會有些悲觀。我常對他們說:‘想象一下:如果我們能幾乎完全預防阿爾茨海默癥,你在七八十歲,甚至幸運的話到九十歲,依然可以健康地承擔祖輩角色,或者如果你愿意,還能繼續工作,這樣的社會如何?’”
蓋茨接著說道:“當然,他們對這種可能性還半信半疑。但他們已經見證了心臟病治療的進步,也看到了癌癥研究的突破。而在這些領域,未來十年,我們會取得更大突破。這是完全可能實現的,而且是件非常令人欣喜的事情。”(財富中文網)
譯者:劉進龍
審校:汪皓
比爾·蓋茨建議,為美國60歲以上人群的常規體檢增加一項新內容:通過血液檢測篩查阿爾茨海默癥風險,并據此提供早期預防性用藥。
這位微軟(Microsoft)創始人長期積極參與全球疾病預防項目。未來幾年,他或將進一步加大在該領域的行動力度。蓋茨已向其慈善基金會下達新任務:他將把自己絕大部分財富(約1,000億美元)捐贈給該基金會,條件是須在未來20年內將這筆資金全部投入使用。
連同現有資產與預期增長在內,其基金會未來可支配的資金總額預計將達到約2,000億美元,重點用于攻克可預防疾病,其中包括蓋茨尤為關注的阿爾茨海默癥。這位科技巨頭的父親老比爾·蓋茨曾罹患阿爾茨海默癥,于2020年去世,享年94歲。
蓋茨對阿爾茨海默癥等疾病的治愈前景有著獨特見解,這不僅源于他的家庭親歷——其家人曾受到這種導致記憶與認知能力退化的腦部疾病影響,也因為他作為全球公共人物,能直接影響各國政策制定者與決策層。
蓋茨指出,從美國的經濟與社會層面來看,治愈阿爾茨海默癥等疾病不僅能減輕家庭負擔,也能緩解社會福利制度的壓力。
蓋茨在接受CBS《周日早晨》節目采訪時表示:“當一個國家進入老齡化社會時,就會出現大量慢性疾病,這些疾病會消耗大量資源?!蔽磥?,富裕且老齡化程度較高的國家將從應對急性病轉向應對慢性病。“因此,集中力量攻克幾種主要疾病是非常明確的當務之急,其中阿爾茨海默癥首當其沖?!?/p>
蓋茨目前正資助多家機構研發基于血液的診斷測試,用以檢測一種名為“淀粉樣蛋白”的特定物質——它被視為阿爾茨海默癥早期發展的關鍵標志物。
蓋茨補充說,理想狀態下,患者應在出現任何癥狀之前就能得到治療。當被問及是否應將阿爾茨海默癥檢測納入常規體檢時,他回答道:“對普通人群而言,大概從60歲起,這應該成為常規血液檢測的一部分。這種檢測成本相對較低,如果這些方法被證明有效,且副作用降低,就應該被納入常規體檢。如果血液檢測顯示淀粉樣蛋白水平偏高,患者就能獲得相應的清除藥物保障?!?/p>
蓋茨表示,這類藥物未來可能以自我注射或靜脈輸液的方式使用,以預防阿爾茨海默癥的發生。但他也指出,要實現這一目標,“仍需完成若干關鍵步驟”。
一直工作到九十歲
人類健康壽命延長帶來的另一個好處是,勞動力規模隨之擴大。當前,各國的決策者既要面對老齡化人口帶來的護理與財政壓力,又要解決因出生率下降而導致的勞動力不足問題。
但蓋茨認為,得益于疾病預防的進步,只要人們愿意,完全可以延長工作年限,在高齡階段繼續從事有意義的工作。這有助于緩解因醫療成本增加而加重的勞動力壓力,從而重新平衡經濟運行所需的人力資源。
他補充說,有些人可能會對這些想法持懷疑態度,“很多人看到一些社會趨勢時會有些悲觀。我常對他們說:‘想象一下:如果我們能幾乎完全預防阿爾茨海默癥,你在七八十歲,甚至幸運的話到九十歲,依然可以健康地承擔祖輩角色,或者如果你愿意,還能繼續工作,這樣的社會如何?’”
蓋茨接著說道:“當然,他們對這種可能性還半信半疑。但他們已經見證了心臟病治療的進步,也看到了癌癥研究的突破。而在這些領域,未來十年,我們會取得更大突破。這是完全可能實現的,而且是件非常令人欣喜的事情?!保ㄘ敻恢形木W)
譯者:劉進龍
審校:汪皓
Bill Gates wants to add a new element to routine medicals for Americans over the age of 60: Blood tests that identify whether the patient may be diagnosed with Alzheimer’s, and as such, be offered preventative medication.
The Microsoft founder is heavily involved with programs to prevent disease across the globe, efforts that will likely ramp up in the coming years after he issued his philanthropic foundation with a task: He would donate the vast majority of his wealth, some $100 billion, to the body as long as the funds are spent within the next 20 years.
The funds, which will total approximately $200 billion between current endowments and projected growth, will focus on curing preventable diseases—one of which Gates hopes will be Alzheimer’s. The tech titan’s father, Bill Gates Sr., died in 2020 at the age of 94, having battled with Alzheimer’s himself.
Gates has unique insight into how an illness like Alzheimer’s—a progressive brain disorder which leads to a decline in memory and skills—can be cured, not only as someone whose family has been impacted by the disease, but also as a public figure with the ear of policy and decision-makers around the world.
From a U.S. perspective, on both an economic and social scale, curing a disease like Alzheimer’s not only alleviates pressure on families, but on the welfare state as well, he said.
“Whenever you have an aging society, you have lots of these chronic diseases that can be a huge drain on resources,” Gates told CBS Sunday morning in a clip aired yesterday. Moving forward, richer, older nations will see a shift from acute medical problems to chronic diseases. “So going after a few diseases, where Alzheimer’s is number one by quite a bit, the imperative is very, very clear,” he added.
As part of his work, Gates is supporting organizations developing blood-based diagnostic tests that identify a specific protein called amyloids, which can be markers for the disease developing.
Ideally, Gates added, patients would be cured of the disease before they ever even started exhibiting symptoms. When asked whether testing for Alzheimer’s should be embedded in wider health checks, Gates responded: “For the broad population, probably once you turn 60 or so, that should be part of the routine blood test. It’s a fairly inexpensive test, and so if these tools prove to work and we get the side-effect level down, then it would become routine that if you test high for the amyloid in your blood then you’d be insured to get those clearing drugs.”
Such medication may be in the form of a self-injection or an infusion, he added, “to prevent you from developing Alzheimer’s.” However, there are “a few steps yet to come together,” he added.
Working into your 90s
With a healthier-for-longer population also comes the benefit of having a larger workforce. At present, policymakers are grappling with the care and cost of an older population, without the same number of workers to replace them due to declining birth rates.
But Gates argues that thanks to prevention, people could work meaningfully longer if they wanted to. This, neatly, would also help rebalance the strain on the workforce needed to power the economy through increased costs of care.
Some people might be skeptical of such ideas, he added: “Many people look at some trends in society and they get a little bit negative. And I say to them: ‘What about a society where we can prevent almost all of Alzheimer’s, and your 70s. 80s, even if you’re luck your 90s, you’re fully capable as grandparent or if you want to continue working.’
“They’re a little skeptical that something like that is happening,” he continued. “They’ve seen progress in heart disease, they’ve seen progress in cancer, but in those, as well as the next 10 years, we are going to get a lot better. And so it’s possible, like wow that is a very positive thing.”